This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclonellin
General Information
DCTPep ID DCTPep02933
Peptide Name Cyclonellin
Sequence ANPRYPYT
Sequence Length 8
UniProt ID Not available
PubChem CID 21576266
Origin Axinella carteri
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50>50 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | IC50>50 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | IC50>50 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ala1<--->Thr8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H64N12O13
Absent amino acids CDEFGHIKLMQSVW
Theoretical pI 8.63
Acidic residues 0
Basic residues 1
Polar residues 4
Molecular weight (Average) 981.08
Molecular weight (Monoisotopic) 980.47
Common amino acids PY
Net charge 1
Instability index (II) -8.89
Aliphatic index 12.50
Grand average of hydropathicity (GRAVY) -1.587
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 3.037
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18428
This work is licensed under a Creative Commons Attribution 4.0 International License.