Cyclonellin

General Information


DCTPep ID  DCTPep02933

Peptide Name   Cyclonellin

Sequence  ANPRYPYT

Sequence Length  8

UniProt ID  Not available

PubChem CID  21576266 

Origin  Axinella carteri

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50>50 µM SRB assay Not available 1
HCT 116 Colon carcinoma IC50>50 µM SRB assay Not available 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia IC50>50 µM SRB assay Not available 1
MDA-MB-231 Breast adenocarcinoma IC50>50 µM SRB assay Not available 1
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm IC50>50 µM SRB assay Not available 1
SNU-638 Gastric adenocarcinoma IC50>50 µM SRB assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Ala1<--->Thr8

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C45H64N12O13

Absent amino acids  CDEFGHIKLMQSVW

Theoretical pI  8.63

Acidic residues  0

Basic residues  1

Polar residues  4

Molecular weight (Average)  981.08

Molecular weight (Monoisotopic)  980.47

Common amino acids  PY

Net charge  1

Instability index (II)  -8.89

Aliphatic index  12.50

Grand average of hydropathicity (GRAVY)  -1.587

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 2980
  Abs 0.1% (=1 g/l) 3.037

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29893558

Title  Cyclopeptides from the Sponge Stylissa flabelliformis

Doi 10.1021/acs.jnatprod.8b00121

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_18428

DCTPep is developed by Dr.Zheng's team.