This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 10
General Information
DCTPep ID DCTPep02938
Peptide Name Phakellistatin 10
Sequence IPYVPLTP
Sequence Length 8
UniProt ID Not available
PubChem CID 44584154
Origin Phakellia sp.
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| P388 | Mouse lymphoma | ED50=2.1 µg/ml | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Glu1<--->Pro8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H70N8O11
Absent amino acids ACDEFGHKMNQRSW
Theoretical pI 5.52
Acidic residues 0
Basic residues 0
Polar residues 2
Molecular weight (Average) 899.1
Molecular weight (Monoisotopic) 898.52
Common amino acids P
Net charge 0
Instability index (II) 29.23
Aliphatic index 133.75
Grand average of hydropathicity (GRAVY) 0.713
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.657
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 7673945
Title Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp
Year 1995
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.