This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 1
General Information
DCTPep ID DCTPep02940
Peptide Name Phakellistatin 1
Sequence PIPIFPY
Sequence Length 7
UniProt ID Not available
PubChem CID 11765991
Origin Phakellia costata; Stylotella aurantium
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| P388 | Mouse lymphoma | ED50=7.5 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Tyr7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H63N7O9
Absent amino acids ACDEGHKLMNQRSTVW
Theoretical pI 5.95
Acidic residues 0
Basic residues 0
Polar residues 1
Molecular weight (Average) 846.04
Molecular weight (Monoisotopic) 845.47
Common amino acids P
Net charge 0
Instability index (II) 31.97
Aliphatic index 111.43
Grand average of hydropathicity (GRAVY) 0.814
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.761
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28335479
Title Phakellistatins: An Underwater Unsolved Puzzle
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.