Peptide Libraray

Phakellistatin 7

General Information

DCTPep ID DCTPep02943

Peptide Name Phakellistatin 7

Sequence PPIFALPPYI

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Phakellia costata

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
P388	Mouse lymphoma	ED50=3.2 μg/mL	Not available	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Pro1<--->Ile10

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C59H86N10O12

Absent amino acids CDEGHKMNQRSTVW

Theoretical pI 5.95

Acidic residues 0

Basic residues 0

Polar residues 1

Molecular weight (Average) 1127.39

Molecular weight (Monoisotopic) 1126.64

Common amino acids P

Net charge 0

Instability index (II) 66.78

Aliphatic index 127.00

Grand average of hydropathicity (GRAVY) 0.970

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.322

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28335479

Title Phakellistatins: An Underwater Unsolved Puzzle

Doi 10.3390/md15030078

Year 2017

Literature 2

Pubmed ID Not available

Title Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7–9

Doi 10.1016/j.tet.2005.04.067

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available