This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 12
General Information
DCTPep ID DCTPep02944
Peptide Name Phakellistatin 12
Sequence PPIFTLPPYI
Sequence Length 10
UniProt ID Not available
PubChem CID 21578711
Origin Phakellia sp.
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| P388 | Mouse lymphoma | ED50=2.8 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ile10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C60H88N10O13
Absent amino acids ACDEGHKMNQRSVW
Theoretical pI 5.95
Acidic residues 0
Basic residues 0
Polar residues 2
Molecular weight (Average) 1157.42
Molecular weight (Monoisotopic) 1156.65
Common amino acids P
Net charge 0
Instability index (II) 66.78
Aliphatic index 117.00
Grand average of hydropathicity (GRAVY) 0.720
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.287
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12639558
Title Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.