This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclopeptide GG-8-6 [L9A]
General Information
DCTPep ID DCTPep03013
Peptide Name Cyclopeptide GG-8-6 [L9A]
Sequence VLPILLLVA
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | IC50=38.64 μM | MTT assay | 24 h | 1 |
| SMMC-7721 | Human papillomavirus-related endocervical adenocarcinoma | IC50=38.92 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Ala9
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H87N9O10
Absent amino acids CDEFGHKMNQRSTWY
Theoretical pI 5.49
Acidic residues 0
Basic residues 0
Polar residues 0
Molecular weight (Average) 950.27
Molecular weight (Monoisotopic) 949.66
Common amino acids L
Net charge 0
Instability index (II) 51.69
Aliphatic index 292.22
Grand average of hydropathicity (GRAVY) 3.144
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29310863
Title Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_20097
This work is licensed under a Creative Commons Attribution 4.0 International License.