Cyclopeptide GG-8-6 [I4A]

General Information


DCTPep ID  DCTPep03018

Peptide Name   Cyclopeptide GG-8-6 [I4A]

Sequence  VLPALLLVL

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Induce apoptosis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
SMMC-7721 Human papillomavirus-related endocervical adenocarcinoma IC50=36.08 μM MTT assay 24 h 1
HepG2 Hepatoblastoma IC50=55.61 μM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Val1<--->Leu9

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C48H87N9O10

Absent amino acids  CDEFGHIKMNQRSTWY

Theoretical pI  5.49

Acidic residues  0

Basic residues  0

Polar residues  0

Molecular weight (Average)  950.27

Molecular weight (Monoisotopic)  949.66

Common amino acids  L

Net charge  0

Instability index (II)  51.69

Aliphatic index  292.22

Grand average of hydropathicity (GRAVY)  3.067

Half Life 
  100 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29310863

Title  Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents

Doi 10.1016/j.bmc.2017.12.028

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_20102

DCTPep is developed by Dr.Zheng's team.