This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclopeptide GG-8-6 (1-7)
General Information
DCTPep ID DCTPep03022
Peptide Name Cyclopeptide GG-8-6 (1-7)
Sequence VLPILLL
Sequence Length 7
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | IC50>100 μM | MTT assay | 24 h | 1 |
| SMMC-7721 | Human papillomavirus-related endocervical adenocarcinoma | IC50>100 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Leu7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C40H73N7O8
Absent amino acids ACDEFGHKMNQRSTWY
Theoretical pI 5.49
Acidic residues 0
Basic residues 0
Polar residues 0
Molecular weight (Average) 780.06
Molecular weight (Monoisotopic) 779.55
Common amino acids L
Net charge 0
Instability index (II) 63.6
Aliphatic index 320.00
Grand average of hydropathicity (GRAVY) 3.186
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29310863
Title Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_20106
This work is licensed under a Creative Commons Attribution 4.0 International License.