XXA4-BH3

General Information


DCTPep ID  DCTPep03027

Peptide Name   XXA4-BH3

Sequence  RPEIWYAQWLKRFGDQFNAYYAR

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-xL

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03027

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C142H196N38O34

Absent amino acids  CHMSTV

Theoretical pI  9.52

Acidic residues  2

Basic residues  4

Polar residues  5

Molecular weight (Average)  2979.35

Molecular weight (Monoisotopic)  2977.48

Common amino acids  ARY

Net charge  2

Instability index (II)  72.4

Aliphatic index  46.96

Grand average of hydropathicity (GRAVY)  -1.013

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 15470
  Abs 0.1% (=1 g/l) 5.192

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25451027

Title  Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL

Doi 10.1016/j.jmb.2014.09.030

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.