This work is licensed under a Creative Commons Attribution 4.0 International License.
XXA1_F3dI-BH3
General Information
DCTPep ID DCTPep03031
Peptide Name XXA1_F3dI-BH3
Sequence RPEIWYAQGLKRIGDEFNAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-xL
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03031
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C130H190N36O35
Absent amino acids CHMSTV
Theoretical pI 8.43
Acidic residues 3
Basic residues 4
Polar residues 6
Molecular weight (Average) 2817.16
Molecular weight (Monoisotopic) 2815.42
Common amino acids ARY
Net charge 1
Instability index (II) 70.31
Aliphatic index 63.91
Grand average of hydropathicity (GRAVY) -0.917
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 9970
Abs 0.1% (=1 g/l) 3.539
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25451027
Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.