This work is licensed under a Creative Commons Attribution 4.0 International License.
Y4eK_18-BH3
General Information
DCTPep ID DCTPep03033
Peptide Name Y4eK_18-BH3
Sequence IWYAQGLKRFGDEFNAYK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| OCI-Ly1 (Bcl-2 dependent) | Diffuse large B-cell lymphoma | EC50=3.325 ± 0.812 μM | Not available | Not available | 1 |
| MDA-MB-231 (Bc1-xL dependent) | Breast adenocarcinoma | EC50=847 ± 284 nM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-xL
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03033
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C105H148N26O27
Absent amino acids CHMPSTV
Theoretical pI 8.43
Acidic residues 2
Basic residues 3
Polar residues 5
Molecular weight (Average) 2206.49
Molecular weight (Monoisotopic) 2205.1
Common amino acids AFGKY
Net charge 1
Instability index (II) 35.99
Aliphatic index 54.44
Grand average of hydropathicity (GRAVY) -0.728
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.843
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25451027
Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.