Peptide Libraray

Y4eK_21-BH3

General Information

DCTPep ID DCTPep03034

Peptide Name Y4eK_21-BH3

Sequence RPEIWYAQGLKRFGDEFNAYK

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-231 (Bc1-xL dependent)	Breast adenocarcinoma	EC50=159 ± 53 nM	Not available	Not available	1
OCI-Ly1 (Bcl-2 dependent)	Diffuse large B-cell lymphoma	EC50=3.435 ± 0.839 μM	Not available	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Bcl-xL

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep03034

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C121H174N32O32

Absent amino acids CHMSTV

Theoretical pI 8.43

Acidic residues 3

Basic residues 4

Polar residues 5

Molecular weight (Average) 2588.91

Molecular weight (Monoisotopic) 2587.3

Common amino acids AEFGKRY

Net charge 1

Instability index (II) 58.9

Aliphatic index 46.67

Grand average of hydropathicity (GRAVY) -1.081

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.276

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25451027

Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL

Doi 10.1016/j.jmb.2014.09.030

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available