BimEL-I146Y

General Information


DCTPep ID  DCTPep03035

Peptide Name   BimEL-I146Y

Sequence  LRPEIRYAQELRRIGDEFNE

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-2/Bcl-xL

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03035

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H174N34O34

Absent amino acids  CHKMSTVW

Theoretical pI  5.01

Acidic residues  5

Basic residues  4

Polar residues  3

Molecular weight (Average)  2504.79

Molecular weight (Monoisotopic)  2503.29

Common amino acids  ER

Net charge  -1

Instability index (II)  103.05

Aliphatic index  83.00

Grand average of hydropathicity (GRAVY)  -1.230

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.595

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30860026

Title  Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Doi 10.7554/eLife.37689

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.