This work is licensed under a Creative Commons Attribution 4.0 International License.
BimEL I146Y-I153M
General Information
DCTPep ID DCTPep03040
Peptide Name BimEL I146Y-I153M
Sequence LRPEIRYAQELRRMGDEFNE
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03040
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C108H172N34O34S1
Absent amino acids CHKSTVW
Theoretical pI 5.01
Acidic residues 5
Basic residues 4
Polar residues 3
Molecular weight (Average) 2522.82
Molecular weight (Monoisotopic) 2521.25
Common amino acids ER
Net charge -1
Instability index (II) 103.05
Aliphatic index 63.50
Grand average of hydropathicity (GRAVY) -1.360
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.591
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30860026
Title Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.