This work is licensed under a Creative Commons Attribution 4.0 International License.
BimEL-CST-2A (R186A-R190A)
General Information
DCTPep ID DCTPep03046
Peptide Name BimEL-CST-2A (R186A-R190A)
Sequence PQMVILQLLAFIFALVWRRH
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03046
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H187N31O23S1
Absent amino acids CDEGKNSTY
Theoretical pI 12.00
Acidic residues 0
Basic residues 3
Polar residues 0
Molecular weight (Average) 2452.05
Molecular weight (Monoisotopic) 2450.41
Common amino acids L
Net charge 3
Instability index (II) 83.33
Aliphatic index 156.00
Grand average of hydropathicity (GRAVY) 1.100
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.243
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30860026
Title Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.