This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim SM-1
General Information
DCTPep ID DCTPep03047
Peptide Name Bim SM-1
Sequence IWIAQELRRIGDEFNA
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 18% Killing= 50 μM | MTT assay | 48 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | 23% Killing= 50 μM | MTT assay | 48 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | 25% Killing= 50 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03047
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C87H135N25O25
Absent amino acids CHKMPSTVY
Theoretical pI 4.68
Acidic residues 3
Basic residues 2
Polar residues 2
Molecular weight (Average) 1931.18
Molecular weight (Monoisotopic) 1930.01
Common amino acids I
Net charge -1
Instability index (II) 69.25
Aliphatic index 110.00
Grand average of hydropathicity (GRAVY) -0.256
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.848
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain
Doi 10.1016/j.cclet.2017.03.010
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.