Bim SM-4

General Information


DCTPep ID  DCTPep03050

Peptide Name   Bim SM-4

Sequence  WIAQELRRIGDEFN

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-2

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03050

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C78H119N23O23

Absent amino acids  CHKMPSTVY

Theoretical pI  4.68

Acidic residues  3

Basic residues  2

Polar residues  2

Molecular weight (Average)  1746.94

Molecular weight (Monoisotopic)  1745.88

Common amino acids  EIR

Net charge  -1

Instability index (II)  77.71

Aliphatic index  90.71

Grand average of hydropathicity (GRAVY)  -0.743

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 3.148

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain

Doi 10.1016/j.cclet.2017.03.010

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.