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Bim SM-4
General Information
DCTPep ID DCTPep03050
Peptide Name Bim SM-4
Sequence WIAQELRRIGDEFN
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03050
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C78H119N23O23
Absent amino acids CHKMPSTVY
Theoretical pI 4.68
Acidic residues 3
Basic residues 2
Polar residues 2
Molecular weight (Average) 1746.94
Molecular weight (Monoisotopic) 1745.88
Common amino acids EIR
Net charge -1
Instability index (II) 77.71
Aliphatic index 90.71
Grand average of hydropathicity (GRAVY) -0.743
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.148
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain
Doi 10.1016/j.cclet.2017.03.010
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.