This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim SM-5
General Information
DCTPep ID DCTPep03051
Peptide Name Bim SM-5
Sequence IAQELRRIGDEF
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | 21% Killing= 50 μM | MTT assay | 48 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | 26% Killing= 50 μM | MTT assay | 48 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 40% Killing= 50 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C63H103N19O20
Absent amino acids CHKMNPSTVWY
Theoretical pI 4.68
Acidic residues 3
Basic residues 2
Polar residues 1
Molecular weight (Average) 1446.63
Molecular weight (Monoisotopic) 1445.76
Common amino acids EIR
Net charge -1
Instability index (II) 89
Aliphatic index 105.83
Grand average of hydropathicity (GRAVY) -0.500
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain
Doi 10.1016/j.cclet.2017.03.010
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.