This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim BH3 (R154S, I155R, E158S)
General Information
DCTPep ID DCTPep03057
Peptide Name Bim BH3 (R154S, I155R, E158S)
Sequence EIWIAQELRSRGDSFNAYYAR
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03057
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C114H169N33O34
Absent amino acids CHKMPTV
Theoretical pI 6.28
Acidic residues 3
Basic residues 3
Polar residues 6
Molecular weight (Average) 2545.8
Molecular weight (Monoisotopic) 2544.25
Common amino acids AR
Net charge 0
Instability index (II) 89.41
Aliphatic index 70.00
Grand average of hydropathicity (GRAVY) -0.738
Half Life
1 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 3.331
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26136077
Title Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.