This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim-FW1
General Information
DCTPep ID DCTPep03077
Peptide Name Bim-FW1
Sequence RPEIWIAQGLRRIGDTWNAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bfl-1 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bfl-1
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03077
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C128H193N39O33
Absent amino acids CFHKMSV
Theoretical pI 9.97
Acidic residues 2
Basic residues 4
Polar residues 6
Molecular weight (Average) 2806.18
Molecular weight (Monoisotopic) 2804.46
Common amino acids R
Net charge 2
Instability index (II) 75.1
Aliphatic index 80.87
Grand average of hydropathicity (GRAVY) -0.730
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 13980
Abs 0.1% (=1 g/l) 4.982
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23363053
Title Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.