Buforin-2 [F10W]

General Information


DCTPep ID  DCTPep03437

Peptide Name   Buforin-2 [F10W]

Sequence  TRSSRAGLQWPVGRVHRLLRK

Sequence Length  21

UniProt ID  P55897 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03437

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C108H185N41O26

Absent amino acids  CDEFIMNY

Theoretical pI  12.60

Acidic residues  0

Basic residues  7

Polar residues  5

Molecular weight (Average)  2473.92

Molecular weight (Monoisotopic)  2472.44

Common amino acids  R

Net charge  7

Instability index (II)  78.61

Aliphatic index  88.10

Grand average of hydropathicity (GRAVY)  -0.814

Half Life 
  7.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.223

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Dimerization of cell-penetrating buforin II enhances antimicrobial properties

Doi Not available

Year  2021

Literature 2

Pubmed ID 10913273

Title  Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: proline as a translocation promoting factor

Doi Not available

Year  2000

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  889

DCTPep is developed by Dr.Zheng's team.