This work is licensed under a Creative Commons Attribution 4.0 International License.
Buforin-2 [F10W]
General Information
DCTPep ID DCTPep03437
Peptide Name Buforin-2 [F10W]
Sequence TRSSRAGLQWPVGRVHRLLRK
Sequence Length 21
UniProt ID P55897
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03437
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C108H185N41O26
Absent amino acids CDEFIMNY
Theoretical pI 12.60
Acidic residues 0
Basic residues 7
Polar residues 5
Molecular weight (Average) 2473.92
Molecular weight (Monoisotopic) 2472.44
Common amino acids R
Net charge 7
Instability index (II) 78.61
Aliphatic index 88.10
Grand average of hydropathicity (GRAVY) -0.814
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.223
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Dimerization of cell-penetrating buforin II enhances antimicrobial properties
Doi Not available
Year 2021
Literature 2
Pubmed ID 10913273
Title Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: proline as a translocation promoting factor
Doi Not available
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 889
This work is licensed under a Creative Commons Attribution 4.0 International License.