This work is licensed under a Creative Commons Attribution 4.0 International License.
Moricin-1
General Information
DCTPep ID DCTPep03438
Peptide Name Moricin-1
Sequence AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
Sequence Length 42
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1KV4
Predicted Structure DCTPep03438
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C208H358N62O51
Absent amino acids CEMQWY
Theoretical pI 11.36
Acidic residues 1
Basic residues 12
Polar residues 9
Molecular weight (Average) 4543.52
Molecular weight (Monoisotopic) 4540.73
Common amino acids K
Net charge 11
Instability index (II) 8.32
Aliphatic index 100.00
Grand average of hydropathicity (GRAVY) -0.210
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Antimicrobial peptide moricin induces ROS mediated caspase-dependent apoptosis in human triple negative breast cancer via suppression of notch pathway
Doi Not available
Year 2022
Literature 2
Pubmed ID 8530391
Title Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori
Doi Not available
Year 1995
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 2135
This work is licensed under a Creative Commons Attribution 4.0 International License.