This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37(1-12)
General Information
DCTPep ID DCTPep03457
Peptide Name LL-37(1-12)
Sequence LLGDFFRKSKEK
Sequence Length 12
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2FBU
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H110N18O18
Absent amino acids ACHIMNPQTVWY
Theoretical pI 9.70
Acidic residues 2
Basic residues 4
Polar residues 2
Molecular weight (Average) 1467.73
Molecular weight (Monoisotopic) 1466.82
Common amino acids K
Net charge 2
Instability index (II) 2.88
Aliphatic index 65.00
Grand average of hydropathicity (GRAVY) -0.933
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Doi Not available
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 3390
This work is licensed under a Creative Commons Attribution 4.0 International License.