This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 (1-4, 17-27)
General Information
DCTPep ID DCTPep03458
Peptide Name LL-37 (1-4, 17-27)
Sequence LLGDFKRIVQRIKDF
Sequence Length 15
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03458
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C86H142N24O21
Absent amino acids ACEHMNPSTWY
Theoretical pI 9.99
Acidic residues 2
Basic residues 4
Polar residues 1
Molecular weight (Average) 1848.22
Molecular weight (Monoisotopic) 1847.08
Common amino acids DFIKLR
Net charge 2
Instability index (II) -0.33
Aliphatic index 123.33
Grand average of hydropathicity (GRAVY) -0.087
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Doi Not available
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 3394
This work is licensed under a Creative Commons Attribution 4.0 International License.