This work is licensed under a Creative Commons Attribution 4.0 International License.
D-Pleurocidin
General Information
DCTPep ID DCTPep03479
Peptide Name D-Pleurocidin
Sequence gwgsffkkaahvgkhvgkaalthyl
Sequence Length 25
UniProt ID P81941
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Calu-3 | Lung adenocarcinoma | IC50=41.9 ± 1.8 μg/ml | XTT assay | 120 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=47.1 ± 2.1 μg/ml | XTT assay | 120 h | 1 |
| A549 | Lung adenocarcinoma | IC50=79.3 ± 7.2 μg/ml | XTT assay | 120 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293: IC50=61.4 ± 3.9 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral D
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 2711.17
Molecular weight (Monoisotopic) 2709.47
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33247193
Title A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy
Doi Not available
Year 2020
Literature 2
Pubmed ID 18779649
Title Structure-antimicrobial activity relationship between pleurocidin and its enantiomer
Doi Not available
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.