This work is licensed under a Creative Commons Attribution 4.0 International License.
Kalata B2
General Information
DCTPep ID DCTPep03483
Peptide Name Kalata B2
Sequence GLPVCGETCFGGTCNTPGCSCTWPICTRD
Sequence Length 29
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2KCH
Predicted Structure DCTPep03483
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H188N34O41S6
Absent amino acids AHKMQY
Theoretical pI 4.37
Acidic residues 2
Basic residues 1
Polar residues 18
Molecular weight (Average) 2979.4
Molecular weight (Monoisotopic) 2977.2
Common amino acids C
Net charge -1
Instability index (II) 47.28
Aliphatic index 36.90
Grand average of hydropathicity (GRAVY) 0.114
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5875
Abs 0.1% (=1 g/l) 1.972, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.846, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25099014
Title Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting
Doi Not available
Year 2014
Literature 2
Pubmed ID 18618891
Title The anthelmintic activity of the cyclotides: natural variants with enhanced activity
Doi Not available
Year 2008
Literature 3
Pubmed ID 28669767
Title Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
Doi Not available
Year 2017
Literature 4
Pubmed ID 15654741
Title Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do M枚bius strips exist in nature?
Doi Not available
Year 2005
Literature 5
Pubmed ID 20564013
Title Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis
Doi Not available
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 5236
This work is licensed under a Creative Commons Attribution 4.0 International License.