Bactenecin-7 (1-23)

General Information


DCTPep ID  DCTPep03486

Peptide Name   Bactenecin-7 (1-23)

Sequence  RRIRPRPPRLPRPRPRPLPFPRP

Sequence Length  23

UniProt ID  P19661 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03486

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C131H222N50O24

Absent amino acids  ACDEGHKMNQSTVWY

Theoretical pI  12.90

Acidic residues  0

Basic residues  9

Polar residues  0

Molecular weight (Average)  2881.52

Molecular weight (Monoisotopic)  2879.77

Common amino acids  P

Net charge  9

Instability index (II)  106.91

Aliphatic index  50.87

Grand average of hydropathicity (GRAVY)  -1.809

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 35578204

Title  Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Doi Not available

Year  2022

Literature 2

Pubmed ID 25525837

Title  Effect of size and N-terminal residue characteristics on bacterial cell penetration and antibacterial activity of the proline-rich peptide Bac7

Doi Not available

Year  2015

Literature 3

Pubmed ID 15572192

Title  Antimicrobial activity of Bac7 fragments against drug-resistant clinical isolates

Doi Not available

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  5245

DCTPep is developed by Dr.Zheng's team.