This work is licensed under a Creative Commons Attribution 4.0 International License.
White cloud bean defensin, Pv-defensin
General Information
DCTPep ID DCTPep03503
Peptide Name White cloud bean defensin, Pv-defensin
Sequence KTCENLADTFRGPCFATSNCDDHCKNKEHLLSGRCRDDFRCWCTRNC
Sequence Length 47
UniProt ID Not available
PubChem CID Not available
Origin Plantae
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03503
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C223H346N74O72S8
Absent amino acids IMQVY
Theoretical pI 7.72
Acidic residues 7
Basic residues 10
Polar residues 20
Molecular weight (Average) 5472.13
Molecular weight (Monoisotopic) 5468.35
Common amino acids C
Net charge 3
Instability index (II) 23.3
Aliphatic index 29.15
Grand average of hydropathicity (GRAVY) -0.923
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6000
Abs 0.1% (=1 g/l) 1.096, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.005, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16687191
Title A mitogenic defensin from white cloud beans (Phaseolus vulgaris)
Doi 10.1016/j.peptides.2006.03.020
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 5850
This work is licensed under a Creative Commons Attribution 4.0 International License.