This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 (15-32)[E1G], GF-17
General Information
DCTPep ID DCTPep03512
Peptide Name LL-37 (15-32)[E1G], GF-17
Sequence GFKRIVQRIKDFLRNLV
Sequence Length 17
UniProt ID P49913
PubChem CID 49777317
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 50% Cytotoxicity=30µM | MTT assay | 18h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2L5M
Predicted Structure DCTPep03512
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C97H164N30O22
Absent amino acids ACEHMPSTWY
Theoretical pI 11.72
Acidic residues 1
Basic residues 5
Polar residues 2
Molecular weight (Average) 2102.56
Molecular weight (Monoisotopic) 2101.26
Common amino acids R
Net charge 4
Instability index (II) 23.91
Aliphatic index 125.88
Grand average of hydropathicity (GRAVY) -0.094
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34959645
Title Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37
Doi Not available
Year 2021
Literature 2
Pubmed ID 32252021
Title Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection
Doi Not available
Year 2021
Literature 3
Pubmed ID 30800727
Title Amino Acid Composition Determines Peptide Activity Spectrum and Hot-Spot-Based Design of Merecidin
Doi Not available
Year 2018
Literature 4
Pubmed ID 19581460
Title Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37
Doi Not available
Year 2009
Literature 5
Pubmed ID 28450045
Title Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes
Doi Not available
Year 2017
Literature 6
Pubmed ID 22083479
Title Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37
Doi Not available
Year 2012
Literature 7
Pubmed ID 20086159
Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database
Doi N
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6070
This work is licensed under a Creative Commons Attribution 4.0 International License.