Brevinin-1ZHb, Amurin-2b
General Information
DCTPep ID DCTPep03531
Peptide Name Brevinin-1ZHb, Amurin-2b
Sequence FLPLLLSALPSFLCLVFKKC
Sequence Length 20
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03531
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C111H178N22O23S2
Absent amino acids DEGHIMNQRTWY
Theoretical pI 8.90
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 2252.89
Molecular weight (Monoisotopic) 2251.29
Common amino acids L
Net charge 2
Instability index (II) 40.51
Aliphatic index 156.00
Grand average of hydropathicity (GRAVY) 1.670
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.055, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29366784
Title Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
Doi Not available
Year 2018
Literature 2
Pubmed ID 22943778
Title Molecular cloning and functional characterization of novel antimicrobial peptides from the skin of brown frog, Rana zhenhaiensis
Doi Not available
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6703