Brevinin-1ZHb, Amurin-2b

General Information


DCTPep ID  DCTPep03531

Peptide Name   Brevinin-1ZHb, Amurin-2b

Sequence  FLPLLLSALPSFLCLVFKKC

Sequence Length  20

UniProt ID  J9R278  G4Y017 

PubChem CID  Not available

Origin  Animalia

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03531

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C111H178N22O23S2

Absent amino acids  DEGHIMNQRTWY

Theoretical pI  8.90

Acidic residues  0

Basic residues  2

Polar residues  4

Molecular weight (Average)  2252.89

Molecular weight (Monoisotopic)  2251.29

Common amino acids  L

Net charge  2

Instability index (II)  40.51

Aliphatic index  156.00

Grand average of hydropathicity (GRAVY)  1.670

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 125
  Abs 0.1% (=1 g/l) 0.055, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29366784

Title  Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues

Doi Not available

Year  2018

Literature 2

Pubmed ID 22943778

Title  Molecular cloning and functional characterization of novel antimicrobial peptides from the skin of brown frog, Rana zhenhaiensis

Doi Not available

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  6703

DCTPep is developed by Dr.Zheng's team.