This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclo(Pro-Phe), Diketopiperazine (PF)
General Information
DCTPep ID DCTPep03534
Peptide Name Cyclo(Pro-Phe), Diketopiperazine (PF)
Sequence PF
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Phe2 (2, 5-diketopiperazine)
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25821788
Title Cytotoxicity of cyclodipeptides from Pseudomonas aeruginosa PAO1 leads to apoptosis in human cancer cell lines
Doi Not available
Year 2015
Literature 2
Pubmed ID 33924262
Title Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A
Doi Not available
Year 2021
Literature 3
Pubmed ID 29351264
Title Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia Solanacearum
Doi Not available
Year 2018
Literature 4
Pubmed ID 30270742
Title Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXRα transcriptional regulation
Doi Not available
Year 2020
Literature 5
Pubmed ID 24622848
Title In vitro antibacterial screening of six proline-based cyclic dipeptides in combination with ?-lactam antibiotics against medically important bacteria
Doi Not available
Year 2014
Literature 6
Pubmed ID 23065379
Title Isolation of proline-based cyclic dipeptides from Bacillus sp N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties
Doi Not
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6742
This work is licensed under a Creative Commons Attribution 4.0 International License.