This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclo(Trp-Pro), Diketopiperazine (WP)
General Information
DCTPep ID DCTPep03544
Peptide Name Cyclo(Trp-Pro), Diketopiperazine (WP)
Sequence WP
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Trp1<--->Pro2 (2, 5-diketopiperazine)
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22409377
Title Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities
Doi Not available
Year 2012
Literature 2
Pubmed ID 32806659
Title C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities
Doi Not available
Year 2020
Literature 3
Pubmed ID 27330275
Title Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp SUK 25 with antimethicillin-resistant Staphylococcus aureus activity
Doi Not available
Year 2016
Literature 4
Pubmed ID 22617493
Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Doi Not available
Year 2012
Literature 5
Pubmed ID 24120705
Title Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria
Doi Not available
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7131
This work is licensed under a Creative Commons Attribution 4.0 International License.