This work is licensed under a Creative Commons Attribution 4.0 International License.
Oncocin
General Information
DCTPep ID DCTPep03555
Peptide Name Oncocin
Sequence VDKPPYLPRPRPPRRIYNR
Sequence Length 19
UniProt ID A0A2R7WNA0
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep03555
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C109H176N36O25
Absent amino acids ACEFGHMQSTW
Theoretical pI 11.45
Acidic residues 1
Basic residues 6
Polar residues 3
Molecular weight (Average) 2390.82
Molecular weight (Monoisotopic) 2389.36
Common amino acids P
Net charge 5
Instability index (II) 62.05
Aliphatic index 56.32
Grand average of hydropathicity (GRAVY) -1.742
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.246
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Design and Characterization of a Novel Hybrid Antimicrobial Peptide OM19R Based on Oncocin and MDAP-2
Doi Not available
Year 2019
Literature 2
Pubmed ID 26334348
Title Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus
Doi Not available
Year 2016
Literature 3
Pubmed ID 31105969
Title Systematic Mutagenesis of Oncocin Reveals Enhanced Activity and Insights into the Mechanisms of Antimicrobial Activity
Doi Not available
Year 2018
Literature 4
Pubmed ID 21185160
Title Bactericidal oncocin derivatives with superior serum stabilities
Doi Not available
Year 2011
Literature 5
Pubmed ID 25730460
Title Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates
Doi Not available
Year 2015
Literature 6
Pubmed ID 20565063
Title Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens
Doi Not available
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7484
This work is licensed under a Creative Commons Attribution 4.0 International License.