This work is licensed under a Creative Commons Attribution 4.0 International License.
Arenicin-3 [Y5N,Y17H], NZ17074, AA230
General Information
DCTPep ID DCTPep03556
Peptide Name Arenicin-3 [Y5N,Y17H], NZ17074, AA230
Sequence GFCWNVCVYRNGVRVCHRRCN
Sequence Length 21
UniProt ID A0A3F2YLM5
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 5Y0I
Predicted Structure DCTPep03556
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C107H165N39O26S4
Absent amino acids ADEIKLMPQST
Theoretical pI 9.37
Acidic residues 0
Basic residues 5
Polar residues 10
Molecular weight (Average) 2541.97
Molecular weight (Monoisotopic) 2540.17
Common amino acids CRV
Net charge 5
Instability index (II) 52.96
Aliphatic index 55.24
Grand average of hydropathicity (GRAVY) -0.243
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 7240
Abs 0.1% (=1 g/l) 2.848, assuming all pairs of Cys residues form cystines
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.750, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30360557
Title Synergistic Effect of Combinations Containing EDTA and the Antimicrobial Peptide AA230, an Arenicin-3 Derivative, on Gram-Negative Bacteria
Doi Not available
Year 2018
Literature 2
Pubmed ID 28611436
Title Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis
Doi Not available
Year 2017
Literature 3
Pubmed ID 28656630
Title Deleting the first disulphide bond in an arenicin derivative enhances its expression in Pichia pastoris
Doi Not available
Year 2017
Literature 4
Pubmed ID 24816779
Title Candidacidal mechanism of the arenicin-3-derived peptide NZ17074 from Arenicola marina
Doi Not available
Year 2014
Literature 5
Pubmed ID 24617894
Title Recombinant production of the antimicrobial peptide NZ17074 in Pichia pastoris using SUMO3 as a fusion partner
Doi Not available
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7485
This work is licensed under a Creative Commons Attribution 4.0 International License.