AMP2041

General Information


DCTPep ID  DCTPep03559

Peptide Name   AMP2041

Sequence  HKCAKIKWRGVHVKYCA

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03559

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C92H147N29O19S2

Absent amino acids  DEFLMNPQST

Theoretical pI  9.90

Acidic residues  0

Basic residues  7

Polar residues  4

Molecular weight (Average)  2027.48

Molecular weight (Monoisotopic)  2026.09

Common amino acids  K

Net charge  7

Instability index (II)  6.66

Aliphatic index  68.82

Grand average of hydropathicity (GRAVY)  -0.447

Half Life 
  3.5 hours (mammalian reticulocytes, in vitro).
  10 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 7115
  Abs 0.1% (=1 g/l) 3.509, assuming all pairs of Cys residues form cystines
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 3.448, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28335779

Title  Activity of AMP2041 against human and animal multidrug resistant Pseudomonas aeruginosa clinical isolates

Doi Not available

Year  2017

Literature 2

Pubmed ID 23893489

Title  In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens

Doi Not available

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  7559

DCTPep is developed by Dr.Zheng's team.