DCTPep ID  DCTPep03560

Peptide Name   Leucrocin I RT2

Sequence  NGVQPKYRWWRWWRRWW

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep03560

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -1.965

Half Life 
  1.4 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 34490
  Abs 0.1% (=1 g/l) 13.542

Amino acid distribution

Literature 1

Pubmed ID 30031283

Title  KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells

Doi Not available

Year  2018

Literature 2

Pubmed ID 27129462

Title  Cationic Antimicrobial Peptides Derived from Crocodylus siamensis Leukocyte Extract, Revealing Anticancer Activity and Apoptotic Induction on Human Cervical Cancer Cells

Doi Not available

Year  2016

Literature 3

Pubmed ID 25767037

Title  Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria

Doi Not available

Year  2015

Literature 4

Pubmed ID 23831136

Title  Improving the antibacterial activity and selectivity of an ultra short peptide by hydrophobic and hydrophilic amino acid stretches

Doi Not available

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  7582