VIH-Buforin-2 (5-21), VIH-sh-Buforin

General Information


DCTPep ID  DCTPep03568

Peptide Name   VIH-Buforin-2 (5-21), VIH-sh-Buforin

Sequence  VIHRAGLQFPVGRVHRLLRK

Sequence Length  20

UniProt ID  P55897 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep03568

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C107H182N38O22

Absent amino acids  CDEMNSTWY

Theoretical pI  12.48

Acidic residues  0

Basic residues  7

Polar residues  2

Molecular weight (Average)  2352.86

Molecular weight (Monoisotopic)  2351.43

Common amino acids  R

Net charge  7

Instability index (II)  52.85

Aliphatic index  126.50

Grand average of hydropathicity (GRAVY)  -0.055

Half Life 
  100 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25891844

Title  Hybrid peptide ATCUN-sh-Buforin: Influence of the ATCUN charge and stereochemistry on antimicrobial activity

Doi Not available

Year  2015

Literature 2

Pubmed ID 24803240

Title  Improved bioactivity of antimicrobial peptides by addition of amino-terminal copper and nickel (ATCUN) binding motifs

Doi Not available

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  7654

DCTPep is developed by Dr.Zheng's team.