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CK21
General Information
DCTPep ID DCTPep03597
Peptide Name CK21
Sequence CNGRCGGKLAKLAKKLAKLAK
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cyc1<--->Cyc5
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C94H175N31O23S2
Absent amino acids DEFHIMPQSTVWY
Theoretical pI 10.32
Acidic residues 0
Basic residues 7
Polar residues 6
Molecular weight (Average) 2171.74
Molecular weight (Monoisotopic) 2170.29
Common amino acids K
Net charge 7
Instability index (II) -11.97
Aliphatic index 93.33
Grand average of hydropathicity (GRAVY) -0.248
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.058, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25990455
Title An antimicrobial peptide containing NGR motif has potent antitumor activity against CD13+ and CD13- tumor cells
Doi Not available
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 8125
This work is licensed under a Creative Commons Attribution 4.0 International License.