Stigmurin

General Information


DCTPep ID  DCTPep03605

Peptide Name   Stigmurin

Sequence  FFSLIPSLVGGLISAFK

Sequence Length  17

UniProt ID  P0DQT1  A0A8I3B021 

PubChem CID  Not available

Origin  Synthetic

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  6VL2 

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C89H138N18O21

Absent amino acids  CDEHMNQRTWY

Theoretical pI  8.75

Acidic residues  0

Basic residues  1

Polar residues  5

Molecular weight (Average)  1796.18

Molecular weight (Monoisotopic)  1795.03

Common amino acids  FLS

Net charge  1

Instability index (II)  12.47

Aliphatic index  137.65

Grand average of hydropathicity (GRAVY)  1.535

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 35526666

Title  In silico and in vitro structure-stability-function relationship of analog peptides of Stigmurin and its antibacterial and antibiofilm activities

Doi Not available

Year  2022

Literature 2

Pubmed ID 29670004

Title  Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity

Doi Not available

Year  2018

Literature 3

Pubmed ID 27567704

Title  Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis

Doi Not available

Year  2016

Literature 4

Pubmed ID 25805002

Title  Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin

Doi Not available

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  8199

DCTPep is developed by Dr.Zheng's team.