Stigmurin
General Information
DCTPep ID DCTPep03605
Peptide Name Stigmurin
Sequence FFSLIPSLVGGLISAFK
Sequence Length 17
UniProt ID P0DQT1 A0A8I3B021
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 6VL2
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C89H138N18O21
Absent amino acids CDEHMNQRTWY
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 5
Molecular weight (Average) 1796.18
Molecular weight (Monoisotopic) 1795.03
Common amino acids FLS
Net charge 1
Instability index (II) 12.47
Aliphatic index 137.65
Grand average of hydropathicity (GRAVY) 1.535
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 35526666
Title In silico and in vitro structure-stability-function relationship of analog peptides of Stigmurin and its antibacterial and antibiofilm activities
Doi Not available
Year 2022
Literature 2
Pubmed ID 29670004
Title Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity
Doi Not available
Year 2018
Literature 3
Pubmed ID 27567704
Title Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis
Doi Not available
Year 2016
Literature 4
Pubmed ID 25805002
Title Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin
Doi Not available
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 8199