DCTPep ID  DCTPep03610

Peptide Name   OsDef2 (16-37)

Sequence  KGIRGYKGGYCKGAFKQTCKCY

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -0.795

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 4595
  Abs 0.1% (=1 g/l) 1.868, assuming all pairs of Cys residues form cystines
  Ext. coefficient 4470
  Abs 0.1% (=1 g/l) 1.817, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 34866278

Title  Antifungal activity and mode of action of Synthetic peptide peptides derived from the tick OsDef2 defensin

Doi Not available

Year  2022

Literature 2

Pubmed ID 31713951

Title  Antimicrobial Function of Short Amidated Peptide Fragments From the Tick-Derived OsDef2 Defensin

Doi Not available

Year  2019

Literature 3

Pubmed ID 26215047

Title  Investigation into the mechanism of action of the antimicrobial peptides Os and Os-C derived from a tick defensin

Doi Not available

Year  2015

Literature 4

Pubmed ID 23553969

Title  Structural and functional characterization of peptides derived from the carboxy-terminal region of a defensin from the tick Ornithodoros savignyi

Doi Not available

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  8286