Peptide Libraray

Cyclotide Vigno 5

General Information

DCTPep ID DCTPep03618

Peptide Name Cyclotide Vigno 5

Sequence GLPLCGETCVGGTCNTPGCSCGWPVCVRN

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin Plantae

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26; NCB: Gly1<--->Asn29

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C117H187N35O38S6

Absent amino acids ADFHIKMQY

Theoretical pI 5.96

Acidic residues 1

Basic residues 1

Polar residues 18

Molecular weight (Average) 2884.34

Molecular weight (Monoisotopic) 2882.21

Common amino acids CG

Net charge 0

Instability index (II) 30.36

Aliphatic index 56.90

Grand average of hydropathicity (GRAVY) 0.317

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5875
Abs 0.1% (=1 g/l) 2.037, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.907, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26751970

Title Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells

Doi Not available

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 8715