Melittin [I17K]

General Information


DCTPep ID  DCTPep03624

Peptide Name   Melittin [I17K]

Sequence  GIGAVLKVLTTGLPALKSWIKRKRQQ

Sequence Length  26

UniProt ID  P01501 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C131H229N39O32

Absent amino acids  CDEFHMNY

Theoretical pI  12.03

Acidic residues  0

Basic residues  6

Polar residues  6

Molecular weight (Average)  2862.5

Molecular weight (Monoisotopic)  2860.75

Common amino acids  KL

Net charge  6

Instability index (II)  41.47

Aliphatic index  120.00

Grand average of hydropathicity (GRAVY)  -0.050

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 1.921

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27011349

Title  Characterization of antimicrobial activity against Listeria and cytotoxicity of native melittin and its mutant variants

Doi Not available

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  8871

DCTPep is developed by Dr.Zheng's team.