This work is licensed under a Creative Commons Attribution 4.0 International License.
Melittin [I17K]
General Information
DCTPep ID DCTPep03624
Peptide Name Melittin [I17K]
Sequence GIGAVLKVLTTGLPALKSWIKRKRQQ
Sequence Length 26
UniProt ID P01501
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C131H229N39O32
Absent amino acids CDEFHMNY
Theoretical pI 12.03
Acidic residues 0
Basic residues 6
Polar residues 6
Molecular weight (Average) 2862.5
Molecular weight (Monoisotopic) 2860.75
Common amino acids KL
Net charge 6
Instability index (II) 41.47
Aliphatic index 120.00
Grand average of hydropathicity (GRAVY) -0.050
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.921
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27011349
Title Characterization of antimicrobial activity against Listeria and cytotoxicity of native melittin and its mutant variants
Doi Not available
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 8871
This work is licensed under a Creative Commons Attribution 4.0 International License.