Dermaseptin PD-1

General Information


DCTPep ID  DCTPep03631

Peptide Name   Dermaseptin PD-1

Sequence  GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ

Sequence Length  31

UniProt ID  A0A0X8XRJ2 

PubChem CID  Not available

Origin  Animalia

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C141H241N39O43S3

Absent amino acids  CFHLNPRVY

Theoretical pI  9.70

Acidic residues  3

Basic residues  6

Polar residues  6

Molecular weight (Average)  3266.88

Molecular weight (Monoisotopic)  3264.7

Common amino acids  A

Net charge  3

Instability index (II)  10.34

Aliphatic index  63.55

Grand average of hydropathicity (GRAVY)  -0.274

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 1.684

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27187467

Title  Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor

Doi Not available

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  9179

DCTPep is developed by Dr.Zheng's team.