This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin PD-1
General Information
DCTPep ID DCTPep03631
Peptide Name Dermaseptin PD-1
Sequence GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ
Sequence Length 31
UniProt ID A0A0X8XRJ2
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C141H241N39O43S3
Absent amino acids CFHLNPRVY
Theoretical pI 9.70
Acidic residues 3
Basic residues 6
Polar residues 6
Molecular weight (Average) 3266.88
Molecular weight (Monoisotopic) 3264.7
Common amino acids A
Net charge 3
Instability index (II) 10.34
Aliphatic index 63.55
Grand average of hydropathicity (GRAVY) -0.274
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.684
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27187467
Title Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor
Doi Not available
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 9179
This work is licensed under a Creative Commons Attribution 4.0 International License.