Laterosporulin 10

General Information


DCTPep ID  DCTPep03647

Peptide Name   Laterosporulin 10

Sequence  ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL

Sequence Length  53

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  6LWZ 

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C265H407N75O75S7

Absent amino acids  S

Theoretical pI  8.30

Acidic residues  5

Basic residues  9

Polar residues  18

Molecular weight (Average)  6068.02

Molecular weight (Monoisotopic)  6063.84

Common amino acids  CGKV

Net charge  4

Instability index (II)  27.35

Aliphatic index  62.45

Grand average of hydropathicity (GRAVY)  -0.428

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11835
  Abs 0.1% (=1 g/l) 1.950, assuming all pairs of Cys residues form cystines
  Ext. coefficient 11460
  Abs 0.1% (=1 g/l) 1.889, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28422156

Title  Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10

Doi Not available

Year  2017

Literature 2

Pubmed ID 27267959

Title  Laterosporulin10: a novel defensin like Class IId bacteriocin from Brevibacillus sp strain SKDU10 with inhibitory activity against microbial pathogens

Doi Not available

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  9529

DCTPep is developed by Dr.Zheng's team.