Laterosporulin 10
General Information
DCTPep ID DCTPep03647
Peptide Name Laterosporulin 10
Sequence ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL
Sequence Length 53
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 6LWZ
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C265H407N75O75S7
Absent amino acids S
Theoretical pI 8.30
Acidic residues 5
Basic residues 9
Polar residues 18
Molecular weight (Average) 6068.02
Molecular weight (Monoisotopic) 6063.84
Common amino acids CGKV
Net charge 4
Instability index (II) 27.35
Aliphatic index 62.45
Grand average of hydropathicity (GRAVY) -0.428
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11835
Abs 0.1% (=1 g/l) 1.950, assuming all pairs of Cys residues form cystines
Ext. coefficient 11460
Abs 0.1% (=1 g/l) 1.889, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28422156
Title Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10
Doi Not available
Year 2017
Literature 2
Pubmed ID 27267959
Title Laterosporulin10: a novel defensin like Class IId bacteriocin from Brevibacillus sp strain SKDU10 with inhibitory activity against microbial pathogens
Doi Not available
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 9529