General Information


DCTPep ID  DCTPep03652

Peptide Name  

Sequence  KWRRWIRWL

Sequence Length  9

UniProt ID  Not available

PubChem CID  49777944 

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C69H102N22O10

Absent amino acids  ACDEFGHMNPQSTVY

Theoretical pI  12.30

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1399.71

Molecular weight (Monoisotopic)  1398.81

Common amino acids  RW

Net charge  4

Instability index (II)  213.53

Aliphatic index  86.67

Grand average of hydropathicity (GRAVY)  -1.311

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 16500
  Abs 0.1% (=1 g/l) 11.788

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30447380

Title  Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

Doi Not available

Year  2019

Literature 2

Pubmed ID 30103288

Title  Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA

Doi Not available

Year  2018

Literature 3

Pubmed ID Not available

Title  A Head-to-Head Comparison of the Antimicrobial Activities of 30 Ultra-Short Antimicrobial Peptides Against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans

Doi Not available

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  9589

DCTPep is developed by Dr.Zheng's team.