V13K [K14k, T15t]

General Information


DCTPep ID  DCTPep03673

Peptide Name   V13K [K14k, T15t]

Sequence  KWKSFLKTFKSAKktVLHTALKAISS

Sequence Length  26

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HPAC Pancreatic adenocarcinoma IC50=22.5 ± 0.5μM MTT assay 24h 1
Bxpc-3 Pancreatic ductal adenocarcinoma IC50=24.1 ± 5.5μM MTT assay 24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=31.6 ± 2.1μM MTT assay 24h 1
MIA PaCa-2 Pancreatic ductal adenocarcinoma IC50=47.1 ± 5.3μM MTT assay 24h 1

Hemolytic Activity  MHC (minimal hemolytic concentration) =250μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29280948

Title  Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of ?-Helical Membrane-Active Peptides

Doi Not available

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  10936

DCTPep is developed by Dr.Zheng's team.