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V13K [S11s, K14k, T15t]
General Information
DCTPep ID DCTPep03674
Peptide Name V13K [S11s, K14k, T15t]
Sequence KWKSFLKTFKsAKktVLHTALKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=41.1 ± 0.5μM | MTT assay | 24h | 1 |
| Bxpc-3 | Pancreatic ductal adenocarcinoma | IC50=45.5 ± 5.6μM | MTT assay | 24h | 1 |
| HPAC | Pancreatic adenocarcinoma | IC50=54.2 ± 1.2μM | MTT assay | 24h | 1 |
| MIA PaCa-2 | Pancreatic ductal adenocarcinoma | IC50=56.8 ± 3.3μM | MTT assay | 24h | 1 |
Hemolytic Activity MHC (minimal hemolytic concentration) =250μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29280948
Title Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of ?-Helical Membrane-Active Peptides
Doi Not available
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 10937
This work is licensed under a Creative Commons Attribution 4.0 International License.