Peptide Libraray

PGYa

General Information

DCTPep ID DCTPep03701

Peptide Name PGYa

Sequence GLLRRLRDFLKKIGEKFKKIGY

Sequence Length 22

UniProt ID Not available

PubChem CID 16130516

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Rous II	Human osteosarcoma cells	>=50% loss of viability=20μM	MTT assay	30min	1
Rous II	Human osteosarcoma cells	>=50% loss of viability=8μM	MTT assay	30min	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C126H212N36O28

Absent amino acids ACHMNPQSTVW

Theoretical pI 10.64

Acidic residues 2

Basic residues 8

Polar residues 4

Molecular weight (Average) 2679.29

Molecular weight (Monoisotopic) 2677.63

Common amino acids K

Net charge 6

Instability index (II) 23.97

Aliphatic index 106.36

Grand average of hydropathicity (GRAVY) -0.577

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.556

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 9428709

Title Design of Synthetic peptide antimicrobial peptides based on sequence analogy and amphipathicity

Doi Not available

Year 1997

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID 11382