This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin DRS-DU-1
General Information
DCTPep ID DCTPep03710
Peptide Name Dermaseptin DRS-DU-1
Sequence ALWKSLLKNVGKAAGKAALNAVTDMVNQ
Sequence Length 28
UniProt ID A0A345FZ90
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | IC50=3.21μM | MTT assay | 24h | 1 |
| H157 | Buccal mucosa squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | IC50=8.43μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C129H219N37O37S1
Absent amino acids CEFHIPRY
Theoretical pI 10.00
Acidic residues 1
Basic residues 4
Polar residues 7
Molecular weight (Average) 2912.44
Molecular weight (Monoisotopic) 2910.61
Common amino acids A
Net charge 3
Instability index (II) 0.25
Aliphatic index 108.21
Grand average of hydropathicity (GRAVY) 0.150
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.888
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30258724
Title Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 11805
This work is licensed under a Creative Commons Attribution 4.0 International License.