This work is licensed under a Creative Commons Attribution 4.0 International License.
TAT(48-57)-G-Dermaseptin DRS-DU-1 (1-13), DP-2
General Information
DCTPep ID DCTPep03712
Peptide Name TAT(48-57)-G-Dermaseptin DRS-DU-1 (1-13), DP-2
Sequence GRKKRRQRRRGALWKSLLKNVGKA
Sequence Length 24
UniProt ID P04610
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| H157 | Buccal mucosa squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | IC50=21.6μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=6.75μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C124H224N50O28
Absent amino acids CDEFHIMPTY
Theoretical pI 12.70
Acidic residues 0
Basic residues 11
Polar residues 5
Molecular weight (Average) 2863.46
Molecular weight (Monoisotopic) 2861.76
Common amino acids R
Net charge 11
Instability index (II) 94.97
Aliphatic index 69.17
Grand average of hydropathicity (GRAVY) -1.550
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.921
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30258724
Title Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 11807
This work is licensed under a Creative Commons Attribution 4.0 International License.